Tertiary lymphoid structures (TLS) are organized immune cell aggregates that assemble within tumors and function as local antitumor immune hubs. Although TLSs have emerged as promising biomarkers of ...
AbstractUveal melanoma is an aggressive tumor type that frequently results in fatal liver metastasis. A better understanding of the interactions between uveal melanoma and host cells in the tumor ...
Abstract. Findings from the phase III WU-KONG28 trial indicate that the next-generation tyrosine kinase inhibitor sunvozertinib, an approved later-line option for patients with non–small cell lung ...
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Abstract:. In the phase I inMMyCAR study of the in vivo chimeric antigen receptor (CAR) T-cell therapy KLN-1010, all 18 patients with multiple myeloma responded. None of the evaluable patients had ...
Abstract:. The treatment arsenal for small cell lung cancer could soon include antibody–drug conjugates, with early data from three phase I studies indicating robust response rates to CD56-targeting ...
AbstractChimeric antigen receptor (CAR) T-cell therapy has shown early promise against glioblastoma, which lacks effective treatment options. However, two key challenges curtail efficacy: ...
AbstractDespite the availability of RAS inhibitors and the dependence of >90% of pancreatic ductal adenocarcinomas (PDAC) on oncogenic KRAS mutations, resistance to KRAS inhibition remains a serious ...
AbstractAnalysis of tumors using single-cell and spatial modalities is critical to advance our understanding of cancer. The growth of technologies that enable these studies provides an increasing ...
Cancer Discov (2026) 16 (6): OF1.
Abstract. Aneuploidy is a hallmark of human tumors. While patient-level copy number alteration (CNA) differences have been investigated extensively in large cohorts, their intratumoral heterogeneity ...
Ming Li Han Liang Jonathan Licht De-Chen Lin Hui-Kuan Lin Piro Lito David Lyden Conor C. Lynch Mathieu Lupien Li Ma Anant Madabhushi Andriy Marusyk Massimiliano Mazzone John D. Minna Lindsay M. Morton ...
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